Each spring, faculty and staff gather for the Charles B. Huggins Research Symposium, an event celebrating the academic accomplishments of the Department – past, present and future. The event features a poster competition, oral presentations and a distinguished keynote speaker.
"Discovery is our business" was Dr. Charles B. Huggins motto and anthem.
Dr. Huggins was the founder and first Director of the Ben May Cancer Laboratory for Cancer Research, in 1951. It was at this time that he demonstrated that breast cancer, like prostate cancer, was dependent on specific hormones. By removing the sources of those hormones, the ovaries and the adrenal glands, which Dr. Huggins showed in 1945 were the source of both male and female hormones, a substantial regression in 30-40% of women with advanced breast cancer was observed.
In 1961, Dr. Huggins developed an experimental mode of human breast cancer in rats. He injected a small dose of aromatic polycyclic hydrocarbons to produce malignant mammary tumors, many of which were hormone dependent. The hormone dependent tumors grew and shrank in response to changes in hormonal balance of the host. The method was known as the "Huggins tumor.” In 1966, Huggins was awarded the Nobel Prize for Physiology and Medicine for his research showing the relationship between hormones and certain cancers. In his most important research, he proved that administration of the female hormone, estrogen, slowed the growth of prostate cancer in males. Hormone therapy, also called androgen ablation, is now a common treatment of prostate cancer.
Charles B. Huggins was born on September 22, 1901, in Halifax, Nova Scotia. He earned his Bachelor of Arts degree in three years from Acadia University in 1920. In 1924, at age 22, he graduated from Harvard Medical School. He served his internship and residency in General Surgery at the University of Michigan. In 1927, he came to The University of Chicago as research fellow, encouraged by the Chair of Surgery, Dallas Phesmister, to take over Urologic Surgery. Having never done any medical research and having no experience in urology, Huggins bought the standard urology textbook and memorized it in three weeks. He became an assistant professor in 1929, associate professor and United States citizen in 1933, and professor in 1936. In the 1950s, Huggins gave up his surgical practice to focus on research full- time. He had won more than 100 awards and honorary degrees.
"Research," Huggins said, "has always been my pleasure as well as my job. There is nothing that matches the thrill of discovery:'
2018 Karl Matlin, PhD
Professor of Surgery, Vice-Chair for Research
The University of Chicago
2017 Narayanan Kasthuri, MD, PhD
Neuroscience Researcher
Argonne National Laboratory
2016 Richard Hodin, MD
Professor of Surgery
Harvard Medical School
2015 Herbert K. Lyerly, MD
Professor of Surgery
Duke University School of Medicine
2014 Allan D. Kirk, MD, PhD
Professor of Surgery, Vice-Chair of Research
Emory University
2013 Yoram Vodovotz, PhD
Professor of Surgery
University of Pittsburgh
2012 Elliot Chaikof, MD, PhD
Professor of Surgery, Chairman
Harvard Medical School
2011 Walter J. Koch, PhD
Professor of Medicine
Thomas Jefferson University
Abstract Competition Winners
Le Shen, PhD:
The Cerebral cavernous malformation disease causing gene KRIT1 regulates epithelial barrier maintenance and regulation
Sara Gaines, MD:
The impact of collagenolytic Enterococcus faecalis on colorectal cancer tumor formation following anastomotic surgery
Lea Hoefer, BA, BS:
The Effect of Margin Status on Multivisceral Resection of Retroperitoneal Sarcoma: Results from a 598 Patient Cohort from the U.S. Sarcoma Collaborative
Poster Competition Winners
Sean Polster, MD:
CASH (Cavernous Angiomas with Symptomatic Hemorrhage) Trial Readiness
Karren Hassan, MD:
Readmission and Revision Rates for Replantation: A Survey of the National Readmission Database
Abstract Competition Winners
Sonia Hernandez, PhD:
Staphylococcus aureus Alpha Toxin Activates Notch 1 in Endothelial Cells and Modulates Angiogenesis In Vivo
Sanjiv Hyoju, MD:
A Novel Drug That Suppresses the Production of Collagenase in Enterococcus faecalis and Enhances Anastomotic Healing
Romuald Girard, PhD:
Plasma Markers of Inflammation Reflect Seizures and Hemorrhagic Activity in Cerebral Cavernous Malformations
Zoë Levine, BA:
The Metabolic Profile of Enterococcus faecalis is Shaped by the Environment of Post-anastomotic Tissues and May Contribute to the Pathogenesis of Leak
Poster Competition Winners
Tony Rodriguez III, MD:
Nephroureterectomy for upper tract urothelial carcinoma: a population-based assessment of utilization and outcomes by surgical approach
Hannah Brechka, BA:
Novel Tumor Suppressor Role for Meis/Hox Axis in Prostate Cancer
Abstract Competition Winners
Gary An, MD:
Avoiding Catastrophe: A proposed participatory modular agent-based modeling approach to the design of a trauma center
Olga Zaborina, PhD:
Extreme physiologic stress causes disappearance of the commensal microbiota from cecal crypts and impairs intestinal epithelium regeneration
Romuald Girard, PhD:
Vascular Permeability and Iron Deposition Biomarkers in Longitudinal Follow-up of Cerebral Cavernous Malformations
Sanjiv Hyoju, PhD:
Oral polyphosphate as the next generation bowel prep: its role in anastomotic leak prevention
Kristina Guyton, MD:
Serial Endoscopic Surveillance after Low Anterior Resection to Understand the Pathogenesis of Anastomotic Leak: Preliminary Results of a Safety and Feasibility Clinical Trial
Chad Teven, MD:
The use of an implantable Doppler to monitor free flap perfusion during vascularized lymph node transfer
Zoe Levine:
Identifying and Quantifying Collagenolytic Species in Human Anastomotic Fluids
Zach Collier:
Stochasticity Among Antibiotic Resistance Profiles Of Common Burn-Related Pathogens Over A Six-Year Period
Poster Competition Winners
Erin McAuley:
The Role of Sox2 in Prostate Epithelium Development, Regeneration and Hyperplasia
Melinda Stack:
NSCLC Sensitivity to Jak2 Inhibition and Identification of PD-L1 as Potential Target of Jak Inhibitor-Based Therapy
Luke Versten:
Morphine and its Major Metabolite Morphine-3-glucuronide after the Phenotype of Enteroccocus Faecalis Increasing its Capacity to Colonize and Disrupt Intestinal Anastomotic Tissues
Hussein A. Zeineddine:
Micro-Computed Tomography in Murine Models of Brain Disease
Abstract Competition Winners
Faculty:
Irina Balyasnikova, PhD
Changbin Shi, PhD
Postgraduates:
Jason Miska, PhD
Julius Kim, PhD
Residents:
Monika Krezalek, MD
Javed Khader Eliyas, MD
Students:
Carolina Mora Solano
Alan Chang
Poster Competition Winners
Zehra Tekin, PhD
Jianjun Chen, PhD
Laura Humphries, MD
Puneet Singh, MD